Question
3. Many chemotherapy drugs used to treat cancer work by modifying the mitotic spindle. Given the...
3. Many chemotherapy drugs used to treat cancer work by modifying the mitotic spindle. Given the short description of the two drugs here, describe how these drugs are effective in stopping cancer cells and where in the cell cycle they are effective. Paclitaxel works by interfering with normal microtubule breakdown during cell division and Vinblastine works by binding tubulin, thereby inhibiting the assembly of microtubules. 4. A researcher has developed three different cell lines that are able to each ignore one of the checkpoints (G1, G2 or M) in the cell cycle. Develop a test (by adding or taking away certain chemicals) that could be used to distinguish and separate the three different cell lines?
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Answer:
Q-3):
- Paclitaxel is inhibiting microtubule breakdown during mitosis.
- So, it is said to be a mitotic cell division inhibitor.
- Especially, the drug inhibits mitosis during separation of daughter cells during telophase.
- Thus paclitaxel, checks continuous division of cells in cancerous tissues.
- This results in programmed cell death of cancerous cells.
- Vinblastine binds tubulin and inhibits assembly of microtubules.
- During metaphase, the chromosome gets arranged on the equatorial plate to get move towards poles during anaphase.
- Due to a check in assembly of microtubules due to vinblastine, the drug inhibits anaphase of mitosis.
- This results in an interruption of continuous cell division in cancerous cells and leads to their death.
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