## Question

###### L ugainst PIu (D) None of these becaus aBan What is one simple ways of attenuating Pseudorabies virus? 9. l ugainst PIu (D) None of these becaus aBan What is one simple ways of attenuating P...

l ugainst PIu (D) None of these becaus aBan What is one simple ways of attenuating Pseudorabies virus? 9.

## Answers

Pseudorabies virus (PrV) is a double-stranded DNA swine virus, with a genome approximating 150 kb in size. PrV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation.

Attenuationmeans taking an infectious agent and alter it to make it harmless or less virulent.PrV has at least 11 different glycoproteins known till date (gB, gC, gD, gE, gG, gH, gI, gK, gL, gM, or gN). gB gD, gH, gL, and gK are essential; the others are considered nonessential.

One simple way to attenuate PrV is to delete gM or replace it with a heterologous gene.For reference check: https://www.ncbi.nlm.nih.gov/pubmed/9292000

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