Question
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F - 0.02; fe - 0.03; t 2-4 hours; Vd- 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL. a. Calculate the infusion rate necessary to maintain b. Calculate how long it will take to reach 90% of c. Calculate the loading dose. a steady state plasma concentration of 3 ug/mL steady state
Answers
1.i already give answer of first question.
2.in 4 th t1/2 the drug will reach 93%steady state concentration.
T1/2=4 hoursSo.it .it is 4x4=16 hours.
So it will take approximately 15 hours to 90% Steady state concentration
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