• Trace the path of a lysosomal enzyme from its point of origin (translation) to its...

A. LYSOSOMAL DEGRADATION Endoplasmic reticulum Nucleus Endocytosis Endosome Senescent organs Phagocytosis Denatured proteins Lysosomes -LC3 Phagosome AUTOPHAGY HETEROPHAGY Autophagosome Phagolysosome Exocytosis

ly sosome fune won endox omes or pragotomes to faciliHate the degradatien of ther contenh. be released into may the eytofol for nution or dizchanged ndo ne expaulllerr space (exocyteaA). End procducty m autophay - sene scent orgamelles br denafurcol pootens are tangeted for lysome-doihen digaadaton them with a dowbli membt clemred brom the endeplasmsc etiendum masked L(3 Pootemx. A brganelles br by eniading by

Lipid, protein building blocks METABOLITES (glucose, glutamine, tatty acids) TCA cycle intermediates Intermembrane space ATP GENERATION (ATP generation) Inner membrane (respiratory chain proteins) APOPTOSIS SIGNALS Outer membrane BAX/BAK complexes Mitochondrion Mitochondrial outer membrane permeabilization (MOMP) Core matrix (citric acid cycle enzymes) Cytochrome C Injury Membrane Stabilized permeability transition pores +H+ apoptosome ISCHEMIA, TOXIN ATP Caspase cascade CELL DEATH CELL DEATH (necrosis) (apoptosis)

ucle Mitochondna proviede the tmt enzymatic machinory for ovido he phosphonyloon The nteomumbame ppace Contams the enzymis such ap enaymes for TCA cyde. TCA cycle egid, proterm, buithing beuga. matechandrial enrynea guerater res ATP Role in ntermediafe Mefabolom popldly groning ulle (camun) atqured fo moke lipid, poteing and nuiex acd. so fhey upregulade the guuose uptake Ord" durcox produeton of ATP.