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Which of the following steps in the G protein signaling Is t0 amplify the signal? A Llgand binding with the receptor B. Contormational change ot the receptor CLigan...

Question

Which of the following steps in the G protein signaling Is t0 amplify the signal? A Llgand binding with the receptor B. Contormational change ot the receptor CLigand dissociation from the receptor Associallon ol tho Ga; CP and Gy E. Production of the second messenger CAMP

Which of the following steps in the G protein signaling Is t0 amplify the signal? A Llgand binding with the receptor B. Contormational change ot the receptor CLigand dissociation from the receptor Associallon ol tho Ga; CP and Gy E. Production of the second messenger CAMP



Answers

When a signaling molecule binds with a receptor, (a) G proteins are inactivated (b) a third messenger is activated (c) cell signaling is terminated (d) CAMP is produced by the receptor (e) the receptor becomes activated

What happens when a peptide binds into a receptor? Let's see this is our peptide. Mhm. And since it's non Polier or if it's too big or polar it won't be able to cross our non polar frost politic violator. And it has to bind into a receptor in order to start the signaling cascade event. So what happens is that the receptor gets activated and once it gets activated it starts to activate the G. Protein just coupled with the receptor and it shoots out the G protein towards the Admiral cyclists. Now the admiral cypress activates the cyclic GMP with the help of some external energy investment of 80 p. Activating our cyclic AMP E. And this is our second receptor signaling receptor. And then this will then call our kindnesses. And the kindnesses would gradually activate other cascades. Like it's a really race. Yeah. By exchanging our phosphate with some more energy cascading eventually activating our um destination. Okay so in this case are G proteins are activated, not inactivated. Our third messenger is not immediately activated but it only activates if our second receptor is activated. And the first thing that actually occurs is that our receptor gets activated immediately after the signaling molecule binds to a receptor, and therefore the answer would be at the receptor will be activated. And also note that the cyclic GMP is not produced by the receptor directly. The cyclic GMP is produced by the adrenal cyclists instead. Yeah. Which is activated by the receptor. But note that the receptor does not produce it like Mp directly. That is it. And thanks for watching. Yeah.

This question asked us to identify the second messenger and a G protein signaling pathway. We're given the pathway. Epinephrine binds the G protein couple receptor, which activates the G protein GTP complex. This activates a dental cycle is causing it to convert a teepee into cyclic GMP. What we need to know is that second messengers are small water soluble ions that easily defused within the cell, meaning they're inside the cell and not proteins nor lipids. We can eliminate G protein and a dental site, please, because they're both proteins and GDP is merely bound to G protein, it hard realizes and general psych ways. This leaves us with C. Clint AM P as a second messenger. Cyclic MP is a small ion and diffuses in the cell rapidly, so the correct answer is a cyclic and P.

Here as what change would have a greater effect on signal amplification and increasing the number of epinephrine receptors or an increase in the number of G office proteins. So the thing that's gonna have the greatest change is going to the increase in number of G Alfa proteins. This is because G Alfa here is going to bind to a dental site, please and effectively amplified the number of CMP. So essentially, in any type of reception here, you can have a small number of signals. However, this is gonna produce eight large response to do to this particular function here.

During the process of signal transaction. There many steps to this process. The initial component of signal transaction begins with reception or recognition at the site of the cellular membrane. So you have your cellular membrane and then embedded in the cellular membrane will be your receptor, which will detect or receive or recognize the environmental stimuli. In this particular problem, epinephrine will act as your like in molecule, which will be in which is from the extra cellular environment. The G protein couple receptor will act as your receptor, which will recognize and lead the recognition step of the signal transaction pathway after epinephrine binds to the G protein coupled receptor as shown here. So this epinephrine is going to bind to the G protein coupled receptor Um, that is located in the cellular remembering Okay, this G protein coupled receptor will undergo a confirmation. I'll change, which will lead to the activation of the G protein, which was which is on the side of Solich side of the cellular membrane. This jeep protein couple, I mean, sorry. This G protein will then transducer this signal to activate another enzyme that's located in cellular membrane, known as a dinner lean cyclists. This identically inside place will undergo chemical reactions and confirmation all changes which will then reap, which will then produce Sigh, click A and P or Camp Sigh click. A MP will then act as the second messenger in this system, which will then activate other affect er's downstream of this signal transaction pathway. So the second messenger in this pathway is sigh, Click A and P.


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