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Inceatend InbreedingICenipatibilit, Hode] Word (Product Activation Failed)TEenoHelailnosRevicy"MeAaBbCcDx AaBbc AaBbCcDd ABCcbd AaBbCc Emphasis Heading Nonme S...

Question

Inceatend InbreedingICenipatibilit, Hode] Word (Product Activation Failed)TEenoHelailnosRevicy"MeAaBbCcDx AaBbc AaBbCcDd ABCcbd AaBbCc Emphasis Heading Nonme Strong SubtitleparaqtadnStyle$smallt adukt sizelouu IQ, loss of unmine finctionand . higher expression of all kinds of genctic disorders (clefi palate , abnoral kxatt function Tay-Sachs diseases, bacmophilia etc ) let'$ anahze how much Wotse produce Inbred child than outbred child Suppose gven locus one grandparent carries deleter

Inceatend Inbreeding ICenipatibilit, Hode] Word (Product Activation Failed) TEeno Helailnos Revicy" Me AaBbCcDx AaBbc AaBbCcDd ABCcbd AaBbCc Emphasis Heading Nonme Strong Subtitle paraqtadn Style$ smallt adukt sizelouu IQ, loss of unmine finctionand . higher expression of all kinds of genctic disorders (clefi palate , abnoral kxatt function Tay-Sachs diseases, bacmophilia etc ) let'$ anahze how much Wotse produce Inbred child than outbred child Suppose gven locus one grandparent carries deleterious rccessnve (frequency population Oo0): Tbe grandparent has two children son and daughter. These two matc WiL cach other, and produce child What is the probability that thc grandparent passes On Lhe defective allele to the son? What the probability that the grandparent passes On the defective allele to the daughter? What 1s the probability that the SOLL passes O1 the defeclive gene Into sperm cell? What Is thc probability that the daughter passes thc detective gene Into egg? What _ the total probability that the sper and egg United in child of the brother-5ister parcntal pair homozygous for the defective gcne? Because the background rate of thc defective gene in 1000,ifthe mother mates With nonrelative, what 1s the probability thar noninbred child of hers will be homozygous for the genctc detect? (Hint; will be her probability ofhating the defective allele Iimes hef probability pDasqng on t0 ncf cgg tule s the probability that randon ~Dcm from the population Will carry the defective gene How much more likely the Inbred child than the outbred child defectite homozygous for the Bene? Calculate the probability the inbred child homozygous and divide bythe probability that the outbred child homozygous)



Answers

Find the probability and answer the questions.Men have XY (or YX) chromosomes and women have XX chromosomes. X-linked recessive genetic diseases (such as juvenile retinoschisis) occur when there is a defective $\mathrm{X}$ chromosome that occurs without a paired $\mathrm{X}$ chromosome that is not defective. In the following, represent a defective $X$ chromosome with lowercase $x,$ so a child with the $x$ Y or Yx pair of chromosomes will have the disease and a child with $X X$ or XY or
YX or $x$ X or $X x$ will not have the disease. Each parent contributes one of the chromosomes to the child.a. If a father has the defective $x$ chromosome and the mother has good XX chromosomes, what
is the probability that a son will inherit the disease?
b. If a father has the defective $x$ chromosome and the mother has good $X X$ chromosomes, what
is the probability that a daughter will inherit the disease?
c. If a mother has one defective $x$ chromosome and one good $X$ chromosome and the father has good XY chromosomes, what is the probability that a son will inherit the disease?
d. If a mother has one defective $x$ chromosome and one good $X$ chromosome and the father has good XY chromosomes, what is the probability that a daughter will inherit the disease?

The diagram showing the crossing off paid in is shown here now on the Waas. Dave's look same since the all represent, though Why is Type CATIC did a stick for each gene, since the above crosses are simple is it does not cause confusion, but in further experiments, it would be wiser to denote it as be positive. Now, the 3rd 1 that is the Fino type, is what believes on but own midriff two seeds. Hence it means that leaves are purple in color by the color brown part pains to seed. It is not significant to write the genes in the same ordered off they re being. The genes can be written in Okay, Me ordered it. Distant is a homo zegas rhesus. If plant, which is used to identify the Gina type off, the if one organism, the me ah tick products in the organism can be seen as the fino type off the progeny

In order to answer this question, let's write down some facts. We know from careful reading of the question that the rabbits that were normal were true breeding. So that means that they have a homeless IBIs state. And so that's a key piece of information for us to solve this problem. And so let's work on a part. A part told us that of the offspring, there were 217 helder anomaly rabbits, and there were 237 normal rabbits, and this is a 1 to 1 ratio. And so, if we think about okay, what were the parents of this off spur of thes offspring in the F one? One of those parents have to be home is itis, so they have to be. Either parents were either big a big A or little, a little A because that's you. That's the definition. True breeding is that normal produces always normal offspring. That tells us that Helder must be headers, I guess because they're different than the normal. But the normal rabbits can only donate one normal alil, and so we know that normal is true breeding. So either big a big a or a little, a little a must be normal. And the headers I go Must be pulgar. Okay, so then let's work through Be part deep Heart says what happens basically if you breathe a poker rabbit with another Kulbir rabbit Well, and so we know that they're headers, August So it's essentially a a situation like this, And here we can do a simple mono hybrid cross and we can put our Leal's from the appropriate windows, and then we can bring them together to represent the offspring. And so when we do that, we know that Helder is going to be the headers idea. So here is the helper, and then one of these is normal, and I'm not sure right now we have enough information to tell, So you're just gonna have to choose one. Um And so I know that helder a wheels are recessive So, um, we know, at least in humans. So here we get 223 normal offspring and this is in the problem. 439 helder offspring and 39 very abnormal. Probably won't make it toe birth if they were born. They die shortly after because they have extensive deformities. Um, and so here, if we look, this is a 1 to 2 to one ratio, and that's what we expect from a breeding between two headers. I get individuals. And so, um, we know that this abnormal one here is lethal. And in humans, those things don't make it to term usually. And so here we have the predicted ratio, where big a big A will say is normal and a little, a little a is lethal and that you expect 2/3 of your surviving offspring to exhibit the abnormal white blood cells, which is characteristic of the pulgar alil. But it's not lethal. Um, because it's not in the home was like estate, so 1 to 2 to rate one ratio and then to answer C part. Since we know a little bit more, they saw the ratios from the problem. In our information, we have that the Pilger polio is a true pick in that In the hitters, I get condition you have a dominant alil that's expressed that produces segmentation of the nucleus and white blood cells. And remember, white blood cells are part of the immune system, and they're responsible for defence against pathogens and foreign particles and in the home is like a state. So little, a little A. It is a lethal condition that organism doesn't or that individual doesn't make it for very long. In life, it's it's born at all. And so, um, if you wanted to investigate Maura about the inheritance pattern to confirm or refuse our hypothesis that when homes I guess recessive conditions are present, its lethal you could do like a statistical analysis to compare litter size with normal versus the elder animals and things like that, um, so that you can determine, um, whether our hypothesis of legality is supported or refuted. And so if we take that information and apply it to the human population, we don't see Pell Grant abnormality very much. If it all, it's extremely rare, and that's because it's a recessive lethal. And so what happens as a recessive lethal in the human population? That means that one in 1000 people have a little A and so if you take too, you know, parents who have big a little a big a little a, and they have a baby that has the lethal condition that's a one in a 1,000,000 chance. And then if you have one out of 1000 random matings that this is gonna happen, then that sort of is to still down toe one case in four million people. And so the baby who has this condition probably doesn't even make it to term. So it's unlikely that the baby even is form. It's probably going to lead to a miscarriage. And so the conditions extremely rare. It probably goes unrecognized in, um, the population. And that's why there's this absence of the public anomaly in humans because it's a recessive, lethal polio, and it's extraordinarily rare. So if we do the cross to support this, what we have is going to a simple pennant square, and we can put our wheels on the appropriate windows, and we can use the information that we've talked about to answer the question and some just bringing these together. And so here we have one. And it's tricky because you don't count the recess of the process of lethal Leo. So it's 1/3 big, a big a normal, and 2/3 will have the Pilger an anomaly. And then this little a little way You don't count because it's lethal. And so, if you look at, um, the anomaly 2/3 chance that they'll have the anomaly. Um, but some of them die, and so they don't survive until birth.


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