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If you used immunofluorescence detect Rho family members; which of the following Rho-family members would you expect to see locally activated at the leading edge of...

Question

If you used immunofluorescence detect Rho family members; which of the following Rho-family members would you expect to see locally activated at the leading edge of a migrating cell?Only RhoOnly RacOnly Cdc42Primarily Rac and Cdc42

If you used immunofluorescence detect Rho family members; which of the following Rho-family members would you expect to see locally activated at the leading edge of a migrating cell? Only Rho Only Rac Only Cdc42 Primarily Rac and Cdc42



Answers

The $19 \mathrm{S}$ subunit of the proteasome contains six subunits that are members of the AAA ATPase family. Other members of this large family are associated into homohexamers with sixfold symmetry. Propose a structure for the AAA ATPases within the 19S proteasome. How might you test and refine your prediction?

Risk Ussing the importance of using to anybody's as opposed to one. So we put picture in an age in which looks somewhere to this y shaped. We have the light chain up here. The heavy chain down here in this region right here is known as the attitude. Now primary anybody's buying to the attitude. They can include four for us, but they bind far less than that of secondary antibodies, which bind to heavy chain A primary. Now these secondary antibodies can include, um, we're floor force than that of primary. So as a result, we could have more of these secondary antibodies, which include more floor for us as opposed thio more primary antibodies, which include less floor force. So this will generate a stronger signal. And we can also have a larger variety of secondary antibodies that find a primary too

In this problem I can write a TX and Ash to P one Plus two. Edge plus one. M. Changes into edge plus one name plus as to me too. But as here and is equal to who he sell is equal to he not sell minus R. B by NF Love PS two by Ph two. So simplifying it further. I can also write the value Heritage plus I can also write the value of the note sale Is equal to zero. It is because he not X. Plus various physical to zero. So you not sell is according to minus. Artie bye to have long We to Buy Me one. So it can be also written Edge plus artie by to have long He won by p. two So option beach, correct. Option V is correct.

Everybody. So this question is giving us a hypothetical scenario. Um, where were asked if we think that our TKs can be, um, activated by antibodies that are going to buy into them and how this would be different with GPC ours, right? So r t k s toe rtk stands for receptor tyrosine. Kindness on these are gonna be signaling kindness. Is that gonna be present on the outside the cells or trans membrane proteins? Um, and they are activated by diamond ization. So But we are T K s R. Activity here is we have one rtk here embedded in the membrane. We have another one over here now, in order for them to become activated, they actually have to come together in Di Marex. And this causes a their kindness activities going too fast for late them. So they're gonna fost for their going to cross phosphor, relate each other, and this is going to activate the signaling cascade here. So this is in contrast with GPC ours, right? So G p c. R stands for G protein coupled receptor the G protein coupled receptors of G, p c. R. And they have use seven. They have these seven trans membrane regions. Right? So one, 234567 So GPC are they're gonna look kind of like this embedded in the membrane. And in order to activate a g p c r, we have to have a specific ligand two receptor interaction here. So a specific Liggins going to come and bind to the GPC are, and that's going to cause a confirmation. I'll change within this membrane brown membrane brown receptor, and that's going to then go ahead and have our intracellular, um, signaling cascade take place. So the GPC ours take are activated by ligand interactions and our receptor tyrosine kindnesses up here are activated by diamond ization. So that brings us to the next part of this question here which is asking us, What do you think an antibody would do you think an antibody would have the ability to activate these receptors? Tiresome kindnesses. And so to think about this question, we should also think about the shape of an antibody. So an antibody is a y shaped protein that has specificity here, the tips of the Y binding specificity. So if we had an antibody that was that could bind to receptor tyrosine, kindnesses. It was specifically receptor tyrosine. Kindnesses. Um imagine antibody here, found here. Wait, are antibody because of the Y shape of our antibody? Um, if we had one receptor tiresome kindness found here So one rtk bound toe, one arm of the antibody, another RTK could come in here bind to this other arm and so, um so we could have another Are DK buying to this other arm? What would that do That would effectively localized these two rt case together. And so it effectively dime arise the rt case. And so that is how are rt case are activated So this demonization would activate them and they would produce the downstream signal. So yes, that Ananta body would have the possibility of activating or rtk here. Now, this is an opposition to RG pcr right, which is activated through ligand interaction. We could have an antibody that would be able to bind to the GPC are. However, in all likelihood, it would find kind of to a random spot in this GPC are, um and what's needed to activate this GPC are is a very specific interaction with a very, um, special begin that's going to induce a very specific confirmation. I'll change, which will go ahead and activate this. GPC are so in all likelihood are antibody could be specific to the GPC are, but it's not going to activate it.

Let us finish the following sentence so that when we read it, it is true when researching how animals specific cell to cell signaling systems have changed over a period of time. I would take a closer look at what. So now let us reread the sentence and fill in the blank properly When researching how animals specific cell to cell signaling systems have changed over a period of time, I would take a closer look at kono menara.


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