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QUESTIONZSynthesise the following target molecules (products) according to the specified route: In all cases Include the retrosynthesis 28 marks will be allocated f...

Question

QUESTIONZSynthesise the following target molecules (products) according to the specified route: In all cases Include the retrosynthesis 28 marks will be allocated for thls step(s) .21Witlig reaction)2.2OEt(Crossed Clalsen Condensation)

QUESTIONZ Synthesise the following target molecules (products) according to the specified route: In all cases Include the retrosynthesis 28 marks will be allocated for thls step(s) . 21 Witlig reaction) 2.2 OEt (Crossed Clalsen Condensation)



Answers

Show how the following target molecules could be synthesized from propene: a. 1 -methoxy- 2 -propanol b. 2-butanol c. 2 -butanone

This question assets to design a multi step synthesis to prepare each of these molecules from the given starting material. So starting with part A, we have a promo cycle hexane, and we're going to go and make an a pox side. So to making a pox, I mean, all keen typically. So I'm going to go ahead and make it all keen by eliminating the bro. Mean? And I'm gonna do that with an E two elimination. So, Teoh, a good way to force an E two is to use a big, bulky base like turkey talk side and heat. Um, and that will give me and Al Keen and then get from an all keen to in a pox side, all you need is a proxy acid that looks like this u r r R C O h, uh, and that will give you an A Parkside for part B. Um, here I have one bromate on my starting material and two on my product. So what I'm gonna do is eliminate the bro mean to get me an AL Keen and then add two bombings back on. So again, I'm gonna eliminated same way I did in part A with a nice bulky base like to repeat oxide and heats to push the elimination, I'll get my AL Keen and then to go from now keen to a trans uh, di bromide here, we're gonna use a Nelkin reaction from the Elkins chapter, which is just be are too. And usually that happens in a solvent like dyke. Laura Methane for part C. I'm going from an all keen into an Alba hide. So what I need to do here is there's a couple different ways that you could do this. You could either turn the l keen into an Al Qaeda and then add the O onto the last carbon. Or I think what I think is easier ways Just add the alcohol onto the end carbon and then oxidize it. So I'm gonna do that. So I'm gonna use be age three in th f. And then, um, water, a drop side and an LH two. Give me, um, hydro operation oxidation to add the alcohol onto the end. Carbon right there. And then I'm gonna oxidize that into an Alba hide using PCC. That's a good oxidizing Asian that will stop at the elder hide instead of going all the way to a car box look after did on a primary alcohol and then for part D. I'm starting with an AL Keen, and I end up with this or to carbon chain off my ring, which is an Al cane, and I end up with this for carbon chain. So what I'm gonna do is I'm gonna first turn this into an all kind so that we can dio um, a reaction that will add the rest of chain on. The way I'm going to do that is by adding and br to on here. So what? I have to leaving groups to eliminate. So we are the r and then I'm going Teoh eliminate both of those. So if I do two times uh, n a N h two that will give me the al kind, it's gonna look like that. And then I want to take this h off of the l kind. So I'm gonna do that again with any NH two and that will give me this Fed allied I on and then with the satellite I on I can add a chain on using an S on to reaction. So I need two more carbons. So I'm gonna use ethyl bromide and that will give me this structure. No, I've added my extra two carbons and then to get to the Al Cane. I'm just going to reduce this Al Qaeda using H two with PDC. So there is my product for party.

Sure which products are expected from psych With mental, I'm going action of a serious off originals? A. So you hide night deep Little needs the alcohol informs on ork oxide, and then substitution with Elko Collide gives you, either through the radiance and reaction missile chloride gives Missile eight, which gives either with soldiers with backside. It's still a vision. Some reaction in this reaction. Some elimination also can be. It's spring. That's so cool, right? But I use this epistle eight, which is e and nuclear physics institution with petition I had died gives your under cycle contain intonation, gives you cycle Pantene in the treatment with, um, de beautiful di metal sile chloride. I will give you the Seidel either and then leverage for the sinew, either with chloride, gives the original alcohol force first. Terrible might in period in substitutes or age for a woman. Fania chloride Impunity in Substitutes or H with Clarion and HBR substitutes rage with women

Hi, everyone. In this question, Charlotte and notations have given. So you have to draw the structure and give the names. So right here as a serial number. Then short hand notation Nord Asia. Mhm. Then you can say structure. Then here began sensing names. So, you know, serial number eight shall turn. Notation is 11. So the structure is ch three. Mm. See the Bondo or age? So they say it's undercut. Monica said name is I'm They can, I can see the next location is 14. So structure is ch three. So you have to rate this like these. And then I just count the number of carbon. I took four confirmations. There should be putting arm 123456789 10, 11, 12, 13 and 14. So 14 carbon atoms are there. This is Petra economic assets. David Brown. Yeah. They cannot speak asset on this one, baby. Let's see. Sure. 22. Yeah. Then in minus nine. So the structure is Wait, It is Yeah, there is a double bond. Yeah. So this was a structure. The name is insect. Of course. 13 in I gassy mhm have been in NYC I see this mhm. So there should be 22 carbons. If he comes, we'll get 22 carbon then next 18 needs to do 18 h two two in minus six. So the structure is like this. Yeah. So this is the structure and the name is nine, said Comma, 12, said the Marine and said, Come on Well said after the call. Oh God, they come 9 12 die in NYC a seed

In this problem, example of a little condensation example of a riddle condensation others follow. So just look at it carefully. I'm writing all the examples who cst th two in presence of dilute any, which it will give Siesta three ch uhh CH two ch two. And the another example is two. See http COCS three in presence of dilute any. Ohh it will give CS three Coh see http CH two G o c s t D. So according to the option obstinacy, each correct answer for this problem.


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