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Provide the synthetic route (the reactions in order) required to make the following compound (1-chloro-3-nitrobenzene) from benzene and any reagents needed:NxoNumbe...

Question

Provide the synthetic route (the reactions in order) required to make the following compound (1-chloro-3-nitrobenzene) from benzene and any reagents needed:NxoNumber the steps for fulcredil Paints for Wsine thelcorrect reagents: points for Jusing the right order !oobtain LhG prodketr

Provide the synthetic route (the reactions in order) required to make the following compound (1-chloro-3-nitrobenzene) from benzene and any reagents needed: Nxo Number the steps for fulcredil Paints for Wsine thelcorrect reagents: points for Jusing the right order !oobtain LhG prodketr



Answers

Use retrosynthetic analysis to show how 3-hexyne can be prepared from acetylene and any other
organic and inorganic compounds. Then draw the synthesis in the synthetic direction, showing all
needed reagents.

This is the answer to Chapter 15. Problem number 13 Fromthe Smith Organic chemistry textbook. Ah, and this problem says show all steps and re agents needed to convert Psychlo. Heck saying into each compound. And so for a were asked to make the two and anti murders of Trans one to die Brohm of Psychlo, heck sane on and for B were asked to make one, too. A poxy cyclo taxi. Okay. Ah, And so immediately above this problem in the textbook Ah, there's the solution to Owen in chapter sample brought home on how to convert from an al came to an AL Keen, and so that's gonna be the first thing that we have to do. Ah, and that is a two step process on. And so the first step of this is going to be a radical perma nation. So we'll use b r two, um, and then some light to do a radical rumination here. Okay. And so we've we've added a brew mean, um, the way that I've had teachers explained this to me is to say that we're putting a handle on an al cane, so something eso alcanzar not reactive, But once we add a broom into them, they become very reactive. And we can do all sorts of other things. So the first step, when we're starting with an Al Kane is always gonna be to add that hey, lied handle that we can grab onto with other re agents and make whatever we need from there. Ah, and so we have this, bro. Mean, we can eliminate it with some potassium turkey tac side, uh, strong base on. So that is gonna get us to the Al Keen. Ah. And so we now have our al Keen, Um, And in order to get the trans one too, bro, most likely or die, bro mo cycle. Heck, saying all that we need to do is treat this out keen that we made with roaming gas. And we will get Trans died rumination. So that is going to look like this. And of course, we will get both on anti Merce. All right, so that's a s. So then for B were asked to make um up oxide. And that is easy enough to dio starting with the final intermediate. Um, from a So the al Keen that we made s a rather than redraw all those steps. And that is a terrible looking out, keen, terrible working cycle axing. Um So rather than redraw all those steps, I'm just gonna start at that that Final Intermediate. Obviously, it would be made the same way that we made it in part of this problem. Let's try this again. Okay, there we go. So here is our Psychlo Heck scene. Um and we can just treat this with M c p b A. It's going to do an approximation. So there we go. Um, in our final product will be the A pox ID. All right, now. And so that's how to solve this problem. Um, again, Uh, the 1st 2 steps that we did our directly from the textbook from right above this problem in the textbook. And then we just need to recall how to do a transformation from the AL keen chapter. Um, and how to make it up oxide with M c p b a. Ah, and that's the answer to Chapter 15. Problem number 13

In this problem, we have to convert to alcohol's first one. See, it's thing. See, it's true. Three extra for it. Oh yeah, One proposal. So see it stayed. See it We are See extra via Thank you, girl. So to growing items can be other. He took albums by In addition, you know that everyone to come home. So if you take responding no longer yeah, it's double want here too. Oh, cool. It is not roaming two propane deals with a group of cocoa. This can be a pink by the higher education of alcohol off preneurs. Using unethical list like satirical, it's toe my message toe. This therefore people the second more interest conversion a few two weeks by works C two, h five or H is converted into C H three. See everyone Oh, c two or C to its way Now pills are made from alcohols and corresponding attics so we can can work. You can get this with a monograph situated by way. Mhm. Uh huh. Pacific gas it see it's three he boy in presence of an Africa trees when you disaster on its own, or can be more your personal that you convert and doing more off. That's if you guys it. What operations with, uh, it's 204 or production diplomat and severely Catholic will also raise this. Do a pretty good on that can be reacted with, uh, either alcohol in business of monastic that leads from the required.

At our retro synthesis where we have our target material and then we essentially need toe work backwards to find our starting materials. So in this fast example, we have the following material. We draw retro synthetic arrow on again one more step before we get to our starting materials. Now this material will go on to react and generate our product. However, we'll just minutes straight onto the second example because what we're looking at is the retro synthesis. That's the most important thing we're considering here. So quite a complex structure to consider firstly, but we have to aromatics and we have an AL kind rats tro synthetic arrow and we replaced our al kind with burr Mean one more retro synthetic arrow to get to our starting materials. In this retro synthesis, people benzene rings on, we have removed the bro mean And now this material will go on to react to get back to the target molecule. In the side example we have here we start off with our benzene attached to a five member ring. Retro synthetic Caro, you touch a brew mean one more retro synthetic arrow. We then remove, said bro mean and this material will go on to react to get our final product looking at the next part, have another aromatic Oh, Keane. Now we can draw a second retro synthesis and we can have one more. This material that is our aromatic, then thes materials. We'll go and react to form our target molecule. Next, we have again a very complex molecule to be drawing out. I'll draw my aromatic is ph for short. We have in our kind for emanated material. Second step in our retro sent the surface because we need to break another bond and this one. So now what we have is three materials that will go on to make this.

Okay, This problem. We have a very open ended question. But we want three different ways to access this compound starting from benzene. Okay, Um, as you can see, there's no functionalities on the benzene ring. So the first thing we'll have to do is let's go ahead and ruminate. So if we use BR too with f d p r three, we can access the perma nated compound. Next we can toss in. Mike needs him solid to generate the vineyard. And finally we can open up on the Parkside. See, it's this final product. Let's see. It's kind of difficult to say certain variations of this, but from the green yeard waken, all also attacked some species like this idol protected alcohol True. And then we could use some of fluoride source. Does he protect he? Second question. This is asking how he can generate then starting from benzene, the seed of phenomena. I don't give you multiple possibilities, but one possibility is again terminate that we have some functional group on this molecule. And then from here we could get the vineyard next we can react with formaldehyde. Generate this pencil ical call. We can oxidize up with P C. C. To generate this How to hide next weekend, React the green eared with the Alba hide. Generate this secondary alcohol. Then we can use PCC again tac size of this key 10 again. You can try different methods on your own to access this. But the most direct route is definitely threw. The Parkside Road is shown here and for the second case. This is also the most direct route. But I challenge you to think of some of your own.


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