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Case Study 4: The Case of Gamora: The Consequences ofan Inability to ComplementDue In class on April 26, 2018 20 ptsCase Study Details: Gamora, 10-year-old female; ...

Question

Case Study 4: The Case of Gamora: The Consequences ofan Inability to ComplementDue In class on April 26, 2018 20 ptsCase Study Details: Gamora, 10-year-old female; arrived at the hospital with symptoms Of meningococcal septicemia and she was diagnosed as having Neisseria meningitidis inlection: Gamora prevlously had meningococeal Infection at the age of 5 years old and has been plagued with nmneruls pyogenie hacterial inlections throughout her Ille:Gamora Was treated wilh 250 [g penicillin MCI

Case Study 4: The Case of Gamora: The Consequences ofan Inability to Complement Due In class on April 26, 2018 20 pts Case Study Details: Gamora, 10-year-old female; arrived at the hospital with symptoms Of meningococcal septicemia and she was diagnosed as having Neisseria meningitidis inlection: Gamora prevlously had meningococeal Infection at the age of 5 years old and has been plagued with nmneruls pyogenie hacterial inlections throughout her Ille: Gamora Was treated wilh 250 [g penicillin MCI daily. Upon trealieet, Gamora fully recovered Iron the bacterial Inlector During her dizgnosis, bloud panef Fevesled tat she has complement protetn € concentration of 0 B/L (normal 0,97-2.0). She had a CS level of 0.2 (normal range 0 0.106 0,263 R/L) and her C Ied Wcte 0.18G/L (HOrmal 0.14 - 0458/L) both ol whch wene Uie [ONJl rJnge Ouarnute Completent protein € $ involved the cumplement p thwJys? Tox Wuulu Compleqent protein Callect specilic Yourreaiee Huudivialuaal umunolvgle_lly? Klene unlat Complement centjin ucteral inlcction ! motereullIn -rcre cd suscepeibility Mcdle utanruLiug ud Gni :n Anah Rtr uetaenal nlections Fher "suscepeibility Co



Answers

A Case History A two-year old child was taken to the hospital. His mother said that he vomited frequently, especially after feedings. The child's weight and physical development were below normal. His hair, although dark, contained patches of white. A urine sample treated with ferric chloride $\left(\mathrm{FeCl}_{3}\right)$ gave a green color characteristic of the presence of phenylpyruvate. Quantitative analysis of urine samples gave the results shown in the table.(TABLE CAN'T COPY) (a) Suggest which enzyme might be deficient in this child. Propose a treatment. (b) Why does phenylalanine appear in the urine in large amounts? (c) What is the source of phenylpyruvate and phenyllactate? Why does this pathway (normally not functional) come into play when the concentration of phenylalanine rises? (d) Why does the boy's hair contain patches of white?

CCD Scientists understanding that one or multiple stressors. One all multiple. Two. Mhm stressors yeah. Can lead to community laws ken. Lead to be cool, unique. Yeah. Gloss. In addition to CCD parasites and pathogens? What? Yeah, parasites and pathogens. Mhm. Mhm. You're nutrition, yeah. Yeah. Mhm. Yeah. Mhm. Okay. Poor nutrition pesticide exposure. Yeah. Yeah. That's right. Let's decide. Ex special lack of genetic diversity, genetic diversity. Mhm. Came weaken. Yeah. Yeah. Or kill. Yeah. Honey bee communist. Oh colonies. Yeah. Yeah. Honey bee called niece. Yeah. Mhm. And a survey in 2007 indicated most. Mhm obvious. Beekeepers believed. Okay, obvious. Mhm. Mhm. Beekeepers, yeah. Come on. Yeah believed. Yeah. That starvation was the leading cause of Mhm. Yeah, starvation. Yeah. Ross yeah. Leading cause of death in the colonies of death in their colonies. Mhm. Yes. Mhm. While commercial beekeepers in their colonies. Mhm. Before, Yeah. And pathogens associated. Yeah. Yeah. Yeah. Vit C C. D. Yeah pathogens are disease causing organism disease hi causing organisms. Yeah. A group of stakeholders. Okay. Yeah. Group of stakeholders. Two that gathered in. Yeah. Okay. 2020. Found in similar consensus. Yeah. Could be. And similar consensus. There's a complex group of stressors. Yeah. Complex mm. Group of mhm stressors and pathogens. Yeah. Yeah. Mhm. Okay. Mhm. Are associated. Yeah wow. Associated bitch. CCD. Mhm. And honey bee colonies. Honey bee colonies. Yeah. Week beginning. Do you too, beekeepers have reportedly. Mhm. Beekeepers. Mhm. Mhm. Reportedly. Yeah. Okay. Lost. Okay. Yeah. 105 240. Yeah. Bee colonies mm. Mhm. Yeah. Bee colonies collapsed on my right. Mhm. Mhm disorder. During the element of yeah. Mhm. Mhm. During during early month. Mhm. Of. Mhm. Those are beasts according to yes. Do you 76%. Mhm. I rise over last year. Yeah. Yeah. Mhm. Our last year. Yeah. And the highest total scenes. Okay. Highest mm Total shins 2016. Yeah.

All right. So this question, but revolves around in a long run study that a 10% increase in the number of Children vaccinated increased the total cost of vaccinations by 8.4%. So is this immunization characterized by economies of scale, this economies of scale or costs and returns? And here we can say that there's economies of scale, right? Let's just say that there's 100 Children in 100 dollar cost. However, once we apply the changes right, a 10% 100 Children times okay, 1.1 or 10% increase is 1 10 in that output size is greater than 100 times 8.4% increase, which it would give us 108.4. Right. And because our output here is greater than our input, we know that we have economies of scale, then moving on to part beat, which is the more difficult part, asking that we can define long run marginal costs, the cost of increasing output by one unit, all units can be very. And so we would say that our long run marginal cost would be less than are longer than average total cost, so we're gonna use kind of this example that we used earlier. We know that our output is 1 10 Our new output in our new inputs or costs is wondered. $8 earn old costs in amount. Children immunized was $100.100 people, so our average little cost here would be equal to $1. However, average total cost characterized by our amount of cost divided by output would be less than one. Be like 90 98 cents, 99 cents somewhere in between. And so since our average total cost is going down, that means that are marginal. Cost must be less than our average total cost or long run. Marginal costs has to be less than a longer than average total cost. Finally, part sees asking us what will the cost of vaccine additional Children prosper? Vaccination has given by current Longwood average total cost with that overestimate on their estimate or accurate, really estimate the cost for additional vaccine. And so I guess at that moment in time, our long run average total cost will be an overestimate because our long run average total cost is decreasing. However, if our marginal cost all right, this in blue. If, if marginal cost becomes greater than average, total cost, then the then other questions other answers can apply. Right? Because if marginal cost rises above our long run marginal costs, excuse me. Rises above are longer on average. Total costs that are longer average, total cost will increase. And that may cause it to be undressed in it or a accurate estimate, so it really can depend here.

Data box Data box is the binding site of data binding protein. Yeah, DPP and other transcription factor. Mhm. Starter box initiate mutations such as insertion deletion and point mutation results in final defect changes petition she was saying What is the start site of transcription Transcription? Start sat transcription start site start at 55 cash and of a gene sequence the state and the structure of DNA four bases heading mean, cytosine going in timing involved. What is the components of transcription? Followings are the components of transcription. Number one promoter number two structural key number three terminator number three terminator.

Complete it had the license off peptide yielded. Equip Melo quantities off Loosen or Norton Personal, Elhanan Pro Lean and Valley. This indicates that the different types of feminizing that the present in the Web died if the number, um so again a number of feminized it is known we can estimate the molecular weight off the peptide. Hence it is estimated Tau Bay 1200. Katie started on treating the peptide with car poxy pep 50 days. It failed to get hydrolyzed, which indicates that the car box three 50 days There's no action on this peptide car. Boxy pep. Today's high July says the car boxes terminology Step days as it has no action on the peptide. It is indicated that there are no free car boxy terminal. And for this peptide okay, Next is treating the peptide with FTN Be Regent, which is followed by a complete Heidel, isis and chromatography. It yielded free immuno assists and derivative off F N f D N b. From this structure, it is evident that the F. D. N V derivative has or nothing, and it it indicates that the end terminal ends has or anything their lives analyzes it is clear that the peptide and dominant ends is Earn Ethan and the sit down and and it's not free. Next, Uh, the DI and Tri baptized that are obtained by the partial hydro leases gives us a hint that the baptizes reputation off, you know, is it. Earlier, it was clear that this reputations are and equal molar quantities from the above step there is from the it is clear that the interminable Emine ISAT IHS or nothing on. If we observed to die peptide or anything, view, you can say that or anything is followed by loosen from the dye peptide flu. Be edgy. It is clear that Lucille is followed by finite element phe pro di that died indicated finance on an espresso, followed by the problem that dry peptide pH a pr ove l gives the information that probably is followed by going when try peptide drive up died B a l o N. And losing is considered. It gives the information that Arnie Pain has failing and loosen on it either side from the earlier assumption. It is a zit is clear that our anything has followed by Listen, we can say that Berlin is present before Arnie Tim again. If we consider the try peptide Mellen, our 10. Do you see? It is being clear that the peptides are being repeated. So by all the verb your girlfriend says, we can say that have died. You know? President 20 obtained from Vassily based Sillas Breakfast, which is and the verdict up Days Properties. It's a sigh. Click only Go peptide that is the core peptide with this Chuck Chuck. Thus we can say well in followed by or Nathan followed by Loosen, followed by finial. Elhanan Fallen that by pro lead, followed by Vallin again. Then again, are Norton, followed by losing, followed by finial 11, Fathered by Problem, then again.


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