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Cytotoxic T cells display the surface antigen ________.CD4MHC IICD8CD12...

Question

Cytotoxic T cells display the surface antigen ________.CD4MHC IICD8CD12

Cytotoxic T cells display the surface antigen ________. CD4 MHC II CD8 CD12



Answers

CD4 proteins on helper and regulatory T cells serve as co-receptors that bind to invariant parts of class II MHC proteins. CD4 is thought to increase the adhesion between T cells and antigen-presenting cells (APCs) that are initially connected only weakly by the T cell receptor bound to its specific peptide-MHC complex. To test this possibility, you label cell-surface MHC molecules with a fluorescently labeled peptide so that you can detect individual peptide-MHC complexes at the interface between the APCs and the T cells in a culture dish. To detect T cell responses-the sign of a productive contact-you load them with a $\mathrm{Ca}^{2+}$ indicator dye, as cytosolic $\mathrm{Ca}^{2+}$ increases when lymphocytes are active. You now count the peptideMHC complexes at a large number of interfaces (immunological synapses and measure the resulting uptake of $\mathrm{Ca}^{2+}$ in the adherent T cells (Figure $Q 24-4$, red circles). When you repeat the experiment in the presence of blocking antibodies against $\mathrm{CD} 4,$ you get a different result (blue circles). Do these results support or refute the notion that CD4 augments T cell receptor binding? Explain your answer.

In this question we need to identify was cited Talks that T cells will bind there TC ours to TC are referring to T sauer SEPTA. Now let's break down side of toxic site. Ill will first to sell toxic. The 1st 2 toxic Now, what instance would a cell become toxic is one It is infected with an interest. Cellular pathogen. Now what usually presents antigens from interest cellular pathogens? That would be M H C one. So this leads us to our answer that sado toxic T cells will bind their TC ours to answer Jin's presented by MHC one.

The major history compel ability Complex is associated with professional Auntie gin presenting cells such as dendritic cells. So this is an antigen presenting cell. And what the I just draw this here in green, The major he's still the MHC class to which is this here are drawn in green will present an exogenous like end, which is what's red there? Two, um CD four t cells. These are the helper T cells.

Is the correct response to Anti Germ on MHC Class two molecules. Should it be a An effect of CD eight kills for presenting self Beat and affect a CD four kills representing self See and affect ER CD eight activates representing so. Oh. D. and effects of CD four activates representing self. Okay we're gonna start with cD four vs. CD eight. So c. d. four is the helper type And CD eight is the site of toxic type. So the site of toxic will be killing a cell and the helper will be activating itself. So let's get rid of the functions that don't match up to the cell type. There we go. So for an mfc too are we seeing a site a toxic So killing representing so or help the T. Cell activating present himself. Well remember Plus two is found on antique antigen presenting cells A. P. C. S. And it presents antibiotic that has been found. Extra cellular lee. So it's anti german. Founds outside the cell and then it is taken into the cell. The pathogen, perhaps a bacterium, is engulfed, broken down and then we have been presented. But the original question was found extra cellular. And because of this the cell is not sick. The cell is not diseased Like you would expect for Anderson found on a class one it's doing its job and it should be activated. Something else is the.

Where this question we need to identify what type off antigens are presented by MHC. Type two molecules to remember that amici type two usually found on a PC's, A PC's are macrophages, dendritic cells and the cells. For this question, we're going to focus on macrophages and dendritic cells. So when a Marco feed your dendritic cell attached to a pathogen, they will engulf it within its follow swarm. Then the life so storm in that macro feed would interdict. So will combine with the fag Elson. The Life Skills Room contains enzymes cell break the pathogen down. These two will create a larger fag ally. So So this leads us to the answer to our question that MHC Type two molecules present foreign antigens. The Arctic created in the Fargo lie so soon.


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