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NHThe best synthesis strategy for the following compound Point)...

Question

NHThe best synthesis strategy for the following compound Point)

NH The best synthesis strategy for the following compound Point)



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Which is the best synthesis of the following cyclopropane?

I guess the rest to create the following compounds. And we're starting with cyclo hexane noon, and we want to create this so we can get alcohol from alcoholic and we can get an alcoholic. Using is your action you are, too, or cl two with either an acid or a base and converting the booming into an alcohol by reacting with sodium hydroxide. It's it would be so. We're not going to trade cycle accident with a strong base because it would department the alpha hydrogen and the three carbon chain is on the beta carbon. So we actually have a 15 dickie to an arrangement. So this is characteristic of the Michael reaction. So we need to turn psycho accident into an Alpha beta saturate cartoon. We can do that by repeating Step One in A. You are to either Ambassador Bass and then treating the alcohol allied with pure dean, your heat. So this will give us an Alpha beta unsaturated ketone and then reacting this with a Michael Dooner. It's only three carbons, so it's super open in, and this will be with with base to departing at the alpha hydrogen. This is going to attack the beta carbon. We get products. This is with water to so for C. We want to create this. So we have a We have a three carbon jean area to carbon chain at the beta carbon again, or a two carbon car box of acid. And it's a carbon car box, like acid is characteristic of the CEO, said Esther. I mean the melodic Esther. But we need an alcohol I to react with the monarch, Esther. So we're gonna turn psycho. Excellent into we're going to add an actual highlight to the beta carbon for the monarch, Esther to attack it. So creating the monarch, Esther, it's going to be, um, actually, let's turn psycho ex saloon. What's adding alcohol? I to the beta carbon. So we're gonna repeat steps one through two N d. Let's get the alphabet and saturate cartoon and they're reacting. This with HBR will give us and alcohol it on the beta carbon and then creating the monarch Esther. So treating this with a strong base, it's gonna pertinent the alpha hydrogen and on psycho accidentally at this. So this is going to attack the alcohol. I'd expelled Alien group. And if we treat this with HCL water and he is going to turn the one Esther into a carb oxalic acid and get rid of the other s during the cartoon. So we'll be left with a two carbon car box like acid There. It's for D. You want to, um, create this compound? So we have a alphabet and saturate cotton an athlete here at Bethel. So if we draw a line between the alpha and beta carbon of the A, keen and the beta and gamma carbon, you can divide the structure in a two. So the only problem this is that we're starting with cyclo hexane in as opposed to these two structures. So you can't really do that. We need to. We basically need to add a a key tuned to the beta carbon, too. Add the method right here. So, for do we want to repeat steps one through two David alpha beta unsaturated ketone. And then we want to turn the apple into a, uh, we want to put a key center in here, so we're gonna use the Michael reaction again to step through is reacting the, um, the alphabet and saturate kitten with a two carbon to carbon key to which is not a hood to the micro action. So far, we have this. So now we want to reduce the kitchen is an alcohol and dehydrate the alcohol so that we can add a key tune right here, as opposed to At the end, is it reducing the key tune with sodium more hydrated and then dehydrate the alcohol with, um, h two as it forever heat to step six, it's gonna get the alcohol back using oxi mercury ation and then turn the alcohol into a key tune using an oxidizing agent like PCC. So now we want to get the arcane back to. So far, we have the structure. So we want to get now keen right here to add to the beta carbon we're gonna use Gilman Regent. So getting the arc in it just steps one through two and B. So now we have the structure and the Gilman region can attack the beta carbon. So it seems that we're gonna use, um, two equivalents of Bethel with copper. With you, we get our products so that we need to get the fo back because we still have a kitchen on this carbon. So far, we have this now. So you got reducing the key tune to an arcane we can actually use, Um, this reaction over ethylene glycol. So that gives us an arcane and then to get rid of the the Yeah, Keane, we're going to react with hydrogen guests with a metal catalyst we get. Our answer is there for E. You want to get this? So because this group is on the alpha carbon, we can actually dip originate the cycle accident. So we're first going to getting a call. He lied. It's gonna be our two with either an acid or heat. And then this is going to, um so in step two, we're actually gonna use the melodic Esther, too. Get the car back silk acid. And this is going to attack the the, um, the carbon right there. The alcohol again. So now department of this with starting with oxide, get the structure, and this is going to attack the alcohol I, the the alpha carbon of cycle accident. And that leaves okay, so, for F, we want to create this and okay, so we can actually deep her near the alcohol region on psycho accident. So we got a carbon out on the alpha carbon, and then this can attack the alcohol. Lied on methyl Berna. Benzene. So the car benign is going to attack this carbon and joined the two structures together. Okay, so for G, this is actually really easy. It's pretty straightforward. Mhm. We're going to urinate the Alpha hydrogen stadium with oxide and then reacting the carbon I with alcohol. I'd soon be a three carbon chain. So it was a three carbon alcohol lied ransacking right there exploded leaving group. And we get our products. So if the last one great this so we can first part near the alpha hydrogen on cyclo. Excellent. So we get a car ban on and then reacting this with I am and asked her. So you need a four carbon chain attached to this carbon 1234 So the purpose of the Ester is that once the carbon carbon is attacked, we'll get not cox, that ion. And once the kids into reforms, it's going to expel the Esther. That's the purpose of having the esters so that the kitchen reforms and it's still balance the four carbon chain. So we have this one three arrangement of the ketones

Okay, so we want to create the following compounds in the given star material. And in the first one we started with a seed afternoon and we want to create the structure. So we're going to add two more carbs. The chain and reacting with a strong base is going to depart at the alpha version. This is going to attack an alcoholic. So I need you to carbon alcohol smuggling group and we get our products and sure be We're starting with a four carbon die Keto ester. I regret this. So we can get a six carbon chain from a 15 tickets and arrangement. So we're gonna modify the structure to get a 15 Dickinson arrangement using the micro reaction. So we're first going to depart the infrastructure with sodium athoc side. This would be the michael dinner and reacting with the michael except er an alfa beta on saturate cotton. This one too 3, 4, 5 and six. So right now we have the structure carbon to is bound to this is for carbon chain. And we're gonna we're going to department this again with uh sodium oxide. So it's gonna grab this hydrogen to carbon out here and this will attack the carbon carbon Check out. This is 1, 2, 3, 4 five and six. Kiss. Carbon five is a key tune. And same with carbon one carbon to is This is 561 carbon too is bound to this group right here. And so if we were if we read your all this, we actually have we won would see to reduce some of the groups. So in the year of the cartoon and turned the keto ester into a two carbon al keen and we can use Wolf Kissner reduction to reduce the cartoon. And it'll turn the key to Esther into a car park stuff acid. So this is going to be um at age two with potassium hydroxide and heat. I'm sorry, hold on, we first want to protect the one key tune. So we're gonna use ethylene glycol, This is three cuz ethylene glycol and then five is going to be wolf Cashner reduction. And this is done with potassium hydroxide and heat. So we're going to get the structure as we draw down here, the keto ester is now a car box like acid. And the one kid that has gone into hydrogen, sir. And here is a protected group. So using um lithium aluminum hydride because we still want protect the cartoon but we want to reduce the carbolic acid into and alcohol and then using a the dehydration reaction H two SF 4 or Heat. So this is going to be 5, 6, seven and then turn the arcane into novocaine with hydrogen gas and a palladium catalyst. So now just removing the protecting group with H syria plus, Which could be H two s at four, just an acid. And we get our products case ever see we want to create a structure. So we're starting with Ben's galahad and why create this? So we have a three Carbon car box of acid. Okay, so this to carbon, carbolic acid is characteristic of the melodic Esther. But we need to tackle Hello to react with Monica faster. So we're gonna turn Gonzaga hot into. We're gonna add a broom in this carbon korean. So first gonna reduce the key soon with the idea of Syrian Border hydride and this is not as strong as lithium aluminum hydride, but you could use that so, and then turning the alcohol into either burning or chlorine bromine. So PBR three, is that reacting with monty Esther? It's your first Indy partner at this. We're gonna carbonara here and then this will attack the alcohol, lad. And we want to add there should be an al keen alphabet to a key in here. So we're first going to treat this with hcl, water and heat. So this is going to turn both esters into car box of acids and heat will get rid of the one car box of acid to have a D. Carb oxidation reaction. And Now we want to get the aachen tyrannies, br two over either acid or base means acetic acid and then reacting this with pure Dean. Ever Heat. Well give us the arcane. Okay, so for D. We have the Matlock Esther and We want to create this five carbon ring, a one carbon carbolic acid. So we're first in a deep coordinate the lock Esther. And if we react this with a 15 Dickey won five Dioko Hillard, we're gonna enter molecular reaction. So reacting this with 15 die chlor oh pence seen It's going to attack the one alcoholic exploration group. So right now we have this, it's pretty carbons. So want to so if we departed at this again with sodium with oxide, we got a carbon out right here and this is going to attack the other actually a lot that's gonna close the ring and then treating this with. That's right now with the structure five carbon ring, treating this with hcl water and heat gives the structure. So this is a good way to get one carbon carbon stock assets as opposed to two. It's actually pretty useful. And I think it's a so four for B. Um Just trying to think here. So you want to make sure you don't have to alcohols in the same structure, because if you use a dehydration reaction, you get a carbon cast iron. The the other alcohol could attack it and you can get an intra molecular reaction to this is why we did it separately.

And this problem were given this flow chart and asked to identify each of the re agents that should be on each arrow. So starting at the top left corner, we're going from an Al Qaeda to Anel cane. We need a really strong reducing agents that will use age to with P. D. C to go from and a terminal out kind to a terminal. AL Keen. We need the one of the regions that will stop the arcane. So either Lynn Lars, Catalyst or sodium and liquid ammonia. But because it's a terminal all kind, we're going to use Lindores Catalyst. So issue with the landmark catalyst, Um, or the next one we're adding to bro means and two hydrogen. Which means that we need, um, and excess of HBR, especially cause those, bro means are on the same carpet. That's why we can't use beer to that would put the Burmese on opposite carbon. So it has to be HBR um, and then for the next one. Now we have one bro meat and one hydrogen. So we're going to use one equivalent of HBR um, going up to the other side. Um, we've made a pox side. Um and that could be done using a proxy acid. But it has to start at an AL Keen. So first will reduce the Al Qaeda to annul Keen. So we'll use issue with the landlord catalysts. And then the second step will be using a proxy acid. Um, so our c 00 H. Is a proxy acid. Um And then for the next one, we have added, Ah hydrogen each carbon and then I roaming in a hydrogen. So first we will reduce with blend Lar and H two. And then we will add HBR to get that bro mean on there The next one we have. And we have a key tone on the internal carbon. So that means that we're going to do a acid catalyzed hydration. And because this is a terminal, all kind will also use the Mercure IQ ion. So we'll have water and acid like issue s 04 and then the Mercury Ion since it is a terminal all kind and then for the last one. Now we have an album hide, which means that the hydration happened on the terminal carbon. So to do that, we will use hydro Operation Oxidation, which is the H three with th f as our first step on our second step is hydroxide peroxide and water.


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