## Question

###### Aspirin is an acid with a $\mathrm{p} K_{\mathrm{a}}$ of $3.5 ;$ its structure includes a carboxyl group. To be absorbed into the bloodstream, it must pass through the membrane lining the stomach and the small intestine. Electrically neutral molecules can pass through a membrane more easily than can charged molecules. Would you expect more aspirin to be absorbed in the stomach, where the pH of gastric juice is about $1,$ or in the small intestine, where the pH is about 6 ? Explain your answer.

Aspirin is an acid with a $\mathrm{p} K_{\mathrm{a}}$ of $3.5 ;$ its structure includes a carboxyl group. To be absorbed into the bloodstream, it must pass through the membrane lining the stomach and the small intestine. Electrically neutral molecules can pass through a membrane more easily than can charged molecules. Would you expect more aspirin to be absorbed in the stomach, where the pH of gastric juice is about $1,$ or in the small intestine, where the pH is about 6 ? Explain your answer.

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