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Activation of AMP kinase leads to an increase in glucose transport: Which step is activated, and in which tissue?GLUT4, muscleHexokinase; adipocytespyruvate dehydro...

Question

Activation of AMP kinase leads to an increase in glucose transport: Which step is activated, and in which tissue?GLUT4, muscleHexokinase; adipocytespyruvate dehydrogenase complex, muscle and liverpyruvate transport; liverGLUT2, liver

Activation of AMP kinase leads to an increase in glucose transport: Which step is activated, and in which tissue? GLUT4, muscle Hexokinase; adipocytes pyruvate dehydrogenase complex, muscle and liver pyruvate transport; liver GLUT2, liver



Answers

In animal tissues, the rate of conversion of pyruvate to acetyl-CoA is regulated by the ratio of active, phosphorylated to inactive, unphosphorylated PDH complex. Determine what happens to the rate of this reaction when a preparation of rabbit muscle mitochondria containing the PDH complex is treated with (a) pyruvate dehydrogenase kinase, ATP, and NADH; (b) pyruvate dehydrogenase phosphatase and $\mathrm{Ca}^{2+} ;$ (c) malonate.

In order to answer this question, we have to identify why muscle. Hi, Rudy. De hydrogen ease is increased upon muscle activity. Okay, well, it all goes back to regulatory control, right? A lot of these biochemical pathways in the body are going to be controlled through various feedback mechanisms. And we find that this regulatory control in question here is going to do with the Peruvian. Di hydrogen is complex. Okay, we sometimes call that the P. D. H complex, and this is going to control the link between okay, our Glen Collis and citric acid cycle. Yeah. So when we find that there's going to be this intense period of muscle activity we would expect for the p d. H to be active Why? Because as we said, pH is going to be involved in controlling the link between colleges and the citric acid cycle. But all of this is referring back to producing ATP. And when there is muscle activity, we're going to need a lot of 80 p to be able to feel that muscle activity. So therefore we find that pH levels are going to be high, and thus we would be able to account for this increase and high levels of ATP. So, um, going back to our answer choices, we find that choice D is going to be the correct answer.

Question here asked. What step in the sea? A MP signaling pathway causes a specific himself response. And this is where it binds to what we know as Kayani's M a piece, which are going to be activation proteins. So the CMP is going to bind to kind of, um, a piece, and essentially, that is going to trigger a downstream in fact, in the nucleus, for example, if the staring hormone where it could affect transcription.

Oh! Thus each that also he also


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